Cancer cells may develop a mechanism that inactivates the drug research is underway to investigate ways of reducing or preventing chemotherapy resistance the development of drug resistance is one reason that drugs are often given in combination.
Preclinically, cancer cell line models are being used to recapitulate the clinical experience, providing 'paired' samples of pretreatment drug-sensitive cells and post-treatment cells that manage to escape the consequences of drug exposure, and these largely isogenic cell line pairs can be compared in order to identify molecular mechanisms of acquired drug resistance. Resistance to these drugs can develop as a result of cancer cells rapidly repairing drug induced lesions , which will be discussed in detail later antimetabolites an example of an antimetabolite is methotrexate, which is a folate antagonist [11.
Mechanisms of drug resistance in cancer chemotherapy luqmani ya(1) author information: (1)department of pharmaceutical chemistry, faculty of pharmacy, kuwait university, kuwait [email protected] the management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy. One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells this is a very serious problem that may lead to recurrence of disease or even death this section is intended to introduce some of the main ways in which cancer cells can resist treatments it is possible that more than one of these resistance mechanisms can occur in any.
Resistance to chemotherapy is when the cancer cells do not respond to the drugs it can be inherented, as a genetic mutation, or it can be acquired, as a cellular response to drug exposure. Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.
In this study, the researchers linked the protection and stabilization of dna replication forks as a major contributory mechanism to drug resistance in brca1/2-mutant breast and ovarian cancers replication is a cellular process that produces two indistinguishable dna copies from a single dna molecule. In addition to the development of drug resistance in cancer progenitor cells and adult cancer cells by the mechanisms previously discussed, another aspect of cancer relapse is the enrichment of drug resistant cancer cells already present in the heterogeneous cancer cell population. These drugs also come from several different families of chemotherapy drugs, so the phenomenon of drug resistance is not confined to one family of cancer drugs or one type of cancer in order to combat resistance, chemotherapy drugs are often given in combination in the hopes that the cancer will fail to resist at least one of the drugs in the. Mechanisms of resistance to pt-based antitumor agents although p-gp, mrp1, and abcg2 are responsible for tumor resistance to many chemotherapeutic drugs cur- rently used in cancer therapy, they play no roles in resistance to pt-based antitumor agents such as cis- platin, carboplatin, and oxaliplatin.
Cancer drug resistance is a complex phenomenon that is influenced by drug inactivation, drug target alteration, drug efflux, dna damage repair, cell death inhibition, emt, inherent cell heterogeneity, epigenetic effects, or any combination of these mechanisms. Cancer chemotherapy resistance (mdr) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy chemotherapy resistance can arise due to several host or tumor-related factors. Chemotherapy resistance occurs when cancers that have been responding to a therapy suddenly begin to grow in other words, the cancer cells are resisting the effects of the chemotherapy you may hear statements like the cancer chemotherapy failed. Also the main mechanism of resistance to these drugs will be explored, particularly focusing on the role of p-glycoprotein and how it can be modulated to reverse drug resistance drugs used in cancer chemotherapy drugs used in the treatment of cancer are summarised in table 2.
However, resistance to another group of chemotherapeutic drugs, ie platinum (pt)-based anti- cancer agents, is caused by different mechanisms in this article, a concise review of the mechanisms of chemo- therapeutic drug resistance is presented. Credit: national cancer institute a laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish dna damage repair in breast cancers that have mutant brca1 or brca2 genes.